ea0038p385 | Steroids | SFEBES2015
Flynn Benjamin P
, Pooley John R
, Kershaw Yvonne M
, Baek Songjoon
, Grontved Lars
, Guertin Michael J
, Hager Gordon L
, Lightman Stafford L
, Conway-Campbell Becky L
Glucocorticoids act via the glucocorticoid receptor (GR). Upon ligand binding, GR translocates to the nucleus and binds directly to glucocorticoid responsive elements (GREs) to regulate transcriptional output. Glucocorticoid secretion increases in response to stress to affect transcriptional output within specific areas of the brain including the hippocampus (HC). Therefore, here we assess changes in genome-wide GR chromatin binding profiles in the rat HC in response to a gluc...